Mechanisms of Human Immunodeficiency Virus Type - 1 Concerted Integration as 1 related to Strand Transfer Inhibition and Drug Resistance 2 3
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چکیده
Mechanisms of Human Immunodeficiency Virus Type-1 Concerted Integration as 1 related to Strand Transfer Inhibition and Drug Resistance 2 3 Jacob A. Zahm + , Sibes Bera +¥ , Krishan K. Pandey +¥ , Ajaykumar Vora + , Kara Stillmock § , 4 Daria Hazuda § , and Duane P. Grandgenett + 5 6 Institute for Molecular Virology, Saint Louis University Health Sciences Center, 7 St. Louis, MO + and Department of Antiviral Research, Merck Research Laboratories, 8 West Point, PA § 9 10 Running Title: Mechanism of HIV-1 Strand Transfer Inhibition 11 Word Count in Abstract: 248 12 Word Count in Text: 5157 13 14 15
منابع مشابه
Inhibition of human immunodeficiency virus type 1 concerted integration by strand transfer inhibitors which recognize a transient structural intermediate.
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) inserts the viral DNA genome into host chromosomes. Here, by native agarose gel electrophoresis, using recombinant IN with a blunt-ended viral DNA substrate, we identified the synaptic complex (SC), a transient early intermediate in the integration pathway. The SC consists of two donor ends juxtaposed by IN noncovalently. The DNA ends w...
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